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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420924 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 40±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420924 | |||
| n/a | |||
| Name | BDBM50420924 | ||
| Synonyms: | CHEMBL2087571 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H37N3O3 | ||
| Mol. Mass. | 451.601 | ||
| SMILES | CCCN(CC1CCOCC1)c1c(CC)nn2c(cccc12)-c1c(OC)cc(C)cc1OC |(-3.23,6.87,;-4.32,5.78,;-3.92,4.3,;-2.41,3.98,;-1.07,5.46,;.45,5.22,;1,3.79,;2.52,3.54,;3.49,4.74,;2.94,6.18,;1.42,6.42,;-1.79,2.07,;-2.7,.83,;-4.24,.83,;-5.01,2.16,;-1.79,-.42,;-.33,.06,;1.01,-.71,;2.34,.06,;2.34,1.6,;1.01,2.37,;-.33,1.6,;1.01,-2.25,;2.34,-3.02,;3.67,-2.25,;5.01,-3.02,;2.34,-4.56,;1.01,-5.33,;1.01,-6.87,;-.33,-4.56,;-.33,-3.02,;-1.66,-2.25,;-2.99,-3.02,)| | ||
| Structure | 
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