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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420925 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 90±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420925 | |||
| n/a | |||
| Name | BDBM50420925 | ||
| Synonyms: | CHEMBL2087572 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H39N3O4 | ||
| Mol. Mass. | 481.627 | ||
| SMILES | CCCN(CC1CCOCC1)c1c(CC)nn2c(cccc12)-c1c(OC)cc(COC)cc1OC |(-3.07,8.08,;-4.18,7.02,;-3.82,5.52,;-2.32,5.17,;-.95,6.63,;.57,6.36,;1.09,4.91,;2.61,4.64,;3.6,5.81,;3.08,7.26,;1.56,7.53,;-1.74,3.26,;-2.67,2.03,;-4.21,2.06,;-4.95,3.41,;-1.79,.76,;-.32,1.21,;1,.41,;2.35,1.15,;2.38,2.69,;1.06,3.49,;-.28,2.75,;.97,-1.13,;2.28,-1.93,;3.63,-1.18,;4.95,-1.98,;2.25,-3.47,;.9,-4.21,;.87,-5.75,;2.19,-6.55,;2.16,-8.08,;-.41,-3.41,;-.38,-1.87,;-1.7,-1.07,;-3.05,-1.81,)| | ||
| Structure | 
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