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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420928 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 120±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420928 | |||
| n/a | |||
| Name | BDBM50420928 | ||
| Synonyms: | CHEMBL2087575 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H37N3O4 | ||
| Mol. Mass. | 479.6111 | ||
| SMILES | COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(C)nn12 |(2.97,-8.96,;2.99,-7.42,;1.67,-6.63,;1.7,-5.09,;3.04,-4.34,;3.06,-2.79,;4.4,-2.05,;5.73,-2.84,;1.74,-2.01,;.39,-2.76,;-.93,-1.97,;-2.28,-2.72,;.37,-4.3,;1.76,-.47,;3.1,.28,;3.13,1.82,;1.8,2.61,;.46,1.86,;-1,2.36,;-1.45,3.83,;-2.93,4.25,;-4.04,3.18,;-5.53,2.8,;-4.46,1.7,;-.41,4.96,;-.86,6.43,;.19,7.56,;-.27,9.03,;-1.77,9.37,;-2.82,8.24,;-2.36,6.77,;-1.92,1.12,;-3.46,1.15,;-1.03,-.13,;.44,.32,)| | ||
| Structure | 
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