Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50420930 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
IC50 | 25±n/a nM | ||
Citation | Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50420930 | |||
n/a | |||
Name | BDBM50420930 | ||
Synonyms: | CHEMBL2087795 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H35N3O4 | ||
Mol. Mass. | 465.5845 | ||
SMILES | COc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(C)cc1OC |(-4.48,1.44,;-3.71,.1,;-2.17,.1,;-1.27,-1.14,;.2,-.67,;1.53,-1.44,;2.87,-.67,;2.87,.87,;1.53,1.64,;.2,.87,;-1.27,1.35,;-1.74,2.81,;-.71,3.96,;.81,3.72,;2.25,4.27,;2.01,2.75,;-3.25,3.13,;-3.65,4.62,;-5.13,5.02,;-5.53,6.51,;-4.44,7.6,;-2.96,7.2,;-2.56,5.71,;1.53,-2.98,;2.86,-3.75,;4.2,-2.98,;5.53,-3.75,;2.86,-5.29,;1.53,-6.06,;1.53,-7.6,;.2,-5.29,;.2,-3.75,;-1.14,-2.98,;-2.47,-3.75,)| | ||
Structure |