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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420931 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840350 (CHEMBL2089414) | ||
| IC50 | 39±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420931 | |||
| n/a | |||
| Name | BDBM50420931 | ||
| Synonyms: | CHEMBL2087796 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H35N3O3S | ||
| Mol. Mass. | 481.65 | ||
| SMILES | COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(SC)nn12 |(5.46,-3.84,;4.14,-3.05,;2.8,-3.8,;2.78,-5.34,;1.43,-6.1,;1.41,-7.64,;.11,-5.31,;.13,-3.77,;-1.19,-2.98,;-2.54,-3.73,;1.47,-3.02,;1.49,-1.48,;2.84,-.72,;2.86,.82,;1.54,1.6,;.19,.85,;-1.27,1.35,;-1.72,2.82,;-.68,3.95,;.84,3.69,;2.29,4.22,;2.02,2.7,;-3.23,3.16,;-3.6,4.65,;-5.09,5.07,;-5.46,6.56,;-4.36,7.64,;-2.88,7.22,;-2.5,5.72,;-2.19,.11,;-3.73,.13,;-4.48,1.48,;-1.3,-1.15,;.17,-.69,)| | ||
| Structure | 
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