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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420933 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 98±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420933 | |||
| n/a | |||
| Name | BDBM50420933 | ||
| Synonyms: | CHEMBL2087797 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H37N3O5S | ||
| Mol. Mass. | 527.675 | ||
| SMILES | COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CCOCC3)CC3(O)CC3)c(SC)nn12 |(3.02,-8.94,;3.01,-7.4,;1.67,-6.64,;1.66,-5.1,;2.99,-4.32,;2.98,-2.78,;4.31,-2,;5.64,-2.76,;1.64,-2.02,;.31,-2.8,;-1.03,-2.04,;-2.36,-2.82,;.32,-4.34,;1.63,-.48,;2.95,.3,;2.94,1.84,;1.6,2.6,;.28,1.82,;-1.19,2.28,;-1.83,4.18,;-3.33,4.49,;-3.74,5.97,;-5.23,6.36,;-5.64,7.85,;-4.56,8.94,;-3.07,8.56,;-2.66,7.07,;-.8,5.33,;.75,5.32,;1.52,6.66,;1,3.81,;2.18,4.79,;-2.09,1.03,;-3.63,1.02,;-4.41,2.34,;-1.17,-.21,;.29,.28,)| | ||
| Structure | 
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