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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420934 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 194±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420934 | |||
| n/a | |||
| Name | BDBM50420934 | ||
| Synonyms: | CHEMBL2087798 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H36N4O4S | ||
| Mol. Mass. | 536.686 | ||
| SMILES | COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CCOCC3)CC3(CC3)C#N)c(SC)nn12 |(2.83,-9,;2.85,-7.46,;1.52,-6.68,;1.53,-5.14,;2.87,-4.38,;2.89,-2.84,;4.23,-2.09,;5.56,-2.87,;1.56,-2.06,;.22,-2.82,;-1.11,-2.04,;-2.45,-2.8,;.21,-4.36,;1.58,-.52,;2.92,.23,;2.93,1.77,;1.6,2.56,;.26,1.8,;-1.2,2.29,;-1.8,4.2,;-3.3,4.53,;-3.69,6.02,;-5.17,6.43,;-5.56,7.93,;-4.46,9,;-2.97,8.59,;-2.59,7.1,;-.76,5.33,;.8,5.32,;1.03,3.8,;2.24,4.77,;1.06,6.84,;1.31,8.36,;-2.11,1.05,;-3.65,1.06,;-4.41,2.41,;-1.22,-.2,;.25,.26,)| | ||
| Structure | 
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