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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420936 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 113±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420936 | |||
| n/a | |||
| Name | BDBM50420936 | ||
| Synonyms: | CHEMBL2087800 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H35N3O5S | ||
| Mol. Mass. | 513.649 | ||
| SMILES | COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3OCCCO3)c(SC)nn12 |(2.87,-8.75,;2.87,-7.21,;1.53,-6.44,;1.53,-4.9,;2.87,-4.13,;2.87,-2.59,;4.2,-1.82,;5.53,-2.59,;1.53,-1.82,;.2,-2.59,;-1.13,-1.82,;-2.47,-2.59,;.2,-4.13,;1.53,-.28,;2.87,.49,;2.87,2.03,;1.53,2.8,;.2,2.03,;-1.27,2.5,;-1.74,3.97,;-.71,5.11,;.81,4.87,;2.25,5.42,;2.01,3.9,;-3.25,4.29,;-3.65,5.78,;-2.56,6.87,;-2.96,8.35,;-4.45,8.75,;-5.53,7.66,;-5.14,6.17,;-2.17,1.26,;-3.71,1.26,;-4.48,2.59,;-1.27,.01,;.2,.49,)| | ||
| Structure | 
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