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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420935 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840350 (CHEMBL2089414) | ||
| IC50 | 180±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420935 | |||
| n/a | |||
| Name | BDBM50420935 | ||
| Synonyms: | CHEMBL2087799 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H35N3O5S | ||
| Mol. Mass. | 513.649 | ||
| SMILES | COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3COCCO3)c(SC)nn12 |(2.79,-8.78,;2.8,-7.24,;1.47,-6.46,;1.48,-4.92,;2.82,-4.16,;2.83,-2.62,;4.17,-1.86,;5.5,-2.64,;1.5,-1.84,;.16,-2.6,;-1.17,-1.82,;-2.5,-2.58,;.15,-4.14,;1.51,-.3,;2.85,.46,;2.86,2,;1.53,2.78,;.19,2.02,;-1.27,2.51,;-1.73,3.98,;-.69,5.11,;.83,4.86,;2.27,5.4,;2.02,3.88,;-3.24,4.31,;-3.62,5.8,;-2.53,6.88,;-2.92,8.37,;-4.4,8.78,;-5.5,7.7,;-5.11,6.21,;-2.18,1.27,;-3.72,1.28,;-4.48,2.62,;-1.28,.02,;.18,.48,)| | ||
| Structure | 
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