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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420929 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840350 (CHEMBL2089414) | ||
| IC50 | 52±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420929 | |||
| n/a | |||
| Name | BDBM50420929 | ||
| Synonyms: | CHEMBL2087794 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H34N4O4 | ||
| Mol. Mass. | 490.594 | ||
| SMILES | COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(nn12)C#N |(2.63,-8.83,;2.66,-7.29,;1.35,-6.49,;1.38,-4.95,;2.73,-4.21,;2.76,-2.67,;4.11,-1.92,;5.43,-2.72,;1.44,-1.87,;.09,-2.61,;-1.23,-1.81,;-2.57,-2.56,;.06,-4.15,;1.47,-.33,;2.82,.41,;2.85,1.95,;1.54,2.75,;.19,2.01,;-1.27,2.51,;-1.71,3.99,;-.66,5.11,;.86,4.84,;2.31,5.36,;2.03,3.84,;-3.21,4.34,;-3.58,5.83,;-5.06,6.26,;-5.43,7.76,;-4.31,8.83,;-2.84,8.4,;-2.47,6.9,;-2.2,1.29,;-1.32,.02,;.16,.47,;-3.74,1.32,;-5.28,1.35,)| | ||
| Structure | 
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