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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50420938 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_840349 (CHEMBL2089413) | ||
| IC50 | 42±n/a nM | ||
| Citation |  Takahashi, Y; Hibi, S; Hoshino, Y; Kikuchi, K; Shin, K; Murata-Tai, K; Fujisawa, M; Ino, M; Shibata, H; Yonaga, M Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem55:5255-69 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50420938 | |||
| n/a | |||
| Name | BDBM50420938 | ||
| Synonyms: | CHEMBL2087564 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H37N3O4 | ||
| Mol. Mass. | 479.6111 | ||
| SMILES | CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(OC)cc1OC |(-4.48,1.81,;-3.71,.48,;-2.17,.49,;-1.26,-.76,;.2,-.28,;1.54,-1.05,;2.87,-.27,;2.87,1.27,;1.53,2.03,;.2,1.26,;-1.27,1.73,;-1.74,3.2,;-.72,4.34,;.8,4.11,;2.24,4.66,;2,3.14,;-3.25,3.51,;-3.65,5,;-5.14,5.4,;-5.54,6.88,;-4.46,7.97,;-2.97,7.58,;-2.57,6.09,;1.54,-2.59,;2.88,-3.35,;4.21,-2.58,;5.54,-3.35,;2.88,-4.89,;1.55,-5.67,;1.55,-7.21,;2.89,-7.97,;.21,-4.9,;.21,-3.36,;-1.13,-2.59,;-2.46,-3.37,)| | ||
| Structure | 
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