Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase 11

Ligand

BDBM50421135

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_839530 (CHEMBL2090337)

IC50

230±n/a nM

Citation

Tynebor, RM; Chen, MH; Natarajan, SR; O'Neill, EA; Thompson, JE; Fitzgerald, CE; O'Keefe, SJ; Doherty, JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett22:5979-83 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 11

Name:

Mitogen-activated protein kinase 11

Synonyms:

Type:

Enzyme

Mol. Mass.:

41390.66

Organism:

Mus musculus (mouse)

Description:

Q9WUI1

Residue:

364

Sequence:

MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTH
EIEQ

BDBM50421135

n/a

Name

BDBM50421135

Synonyms:

CHEMBL2088577

Type

Small organic molecule

Emp. Form.

C26H21F2N3O3

Mol. Mass.

461.46

SMILES

CCc1ccc(cc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O)C(=O)NC1CC1 |(31.2,-29.1,;32.53,-29.87,;33.87,-29.1,;33.87,-27.56,;35.2,-26.79,;36.53,-27.55,;36.54,-29.1,;35.2,-29.87,;35.2,-31.41,;36.53,-32.17,;37.85,-31.41,;39.18,-32.16,;39.19,-33.7,;40.52,-34.46,;40.53,-36,;39.19,-36.78,;39.2,-38.31,;40.54,-39.08,;40.55,-40.62,;41.87,-38.3,;41.86,-36.76,;43.19,-35.98,;37.86,-34.47,;36.54,-33.71,;35.2,-34.49,;33.87,-33.71,;33.87,-32.18,;32.54,-31.4,;37.86,-26.77,;37.86,-25.23,;39.2,-27.54,;40.53,-26.76,;42.07,-26.76,;41.29,-25.43,)|

Structure