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TargetMitogen-activated protein kinase 11
LigandBDBM50421136
Substrate/Competitorn/a
Meas. Tech.ChEMBL_839530 (CHEMBL2090337)
IC50 140±n/a nM
Citation Tynebor, RM; Chen, MH; Natarajan, SR; O'Neill, EA; Thompson, JE; Fitzgerald, CE; O'Keefe, SJ; Doherty, JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett22:5979-83 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 11
Name:Mitogen-activated protein kinase 11
Synonyms:MAP Kinase p38 beta | MK11_MOUSE | Mapk11 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | Prkm11 | p38B
Type:Enzyme
Mol. Mass.:41390.66
Organism:Mus musculus (mouse)
Description:Q9WUI1
Residue:364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTH
EIEQ
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BDBM50421136
n/a
NameBDBM50421136
Synonyms:CHEMBL2088587
TypeSmall organic molecule
Emp. Form.C21H14F2N2O3
Mol. Mass.380.3443
SMILESCOc1ccccc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O |(-12.43,-43.9,;-11.09,-44.67,;-9.75,-43.9,;-9.75,-42.36,;-8.42,-41.59,;-7.08,-42.35,;-7.08,-43.9,;-8.42,-44.68,;-8.41,-46.21,;-7.08,-46.98,;-5.76,-46.21,;-4.44,-46.97,;-4.43,-48.51,;-3.09,-49.27,;-3.08,-50.81,;-4.42,-51.59,;-4.41,-53.13,;-3.08,-53.89,;-3.07,-55.44,;-1.74,-53.11,;-1.75,-51.57,;-.42,-50.79,;-5.75,-49.28,;-7.08,-48.51,;-8.42,-49.3,;-9.75,-48.52,;-9.75,-46.98,;-11.09,-46.21,)|
Structure
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