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TargetMAP kinase p38 beta
LigandBDBM50421140
Substrate/Competitorn/a
Meas. Tech.ChEMBL_839530
IC50 8.5±n/a nM
Citation Tynebor RMChen MHNatarajan SRO'Neill EAThompson JEFitzgerald CEO'Keefe SJDoherty JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett 22:5979-83 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
MAP kinase p38 beta
Name:MAP Kinase p38 beta
Synonyms:Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | p38B
Type:Enzyme
Mol. Mass.:41390.66
Organism:Mus musculus (mouse)
Description:Q9WUI1
Residue:364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTH
EIEQ
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  Blast E-value cutoff:
BDBM50421140
n/a
NameBDBM50421140
Synonyms:CHEMBL2088591
TypeSmall organic molecule
Emp. Form.C24H16F2N4O4
Mol. Mass.462.405
SMILESCOc1ccc(cc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O)-c1nnc(C)o1 |(33.77,-46.54,;35.1,-47.32,;36.43,-46.55,;36.44,-45,;37.77,-44.23,;39.1,-45,;39.11,-46.55,;37.77,-47.32,;37.77,-48.85,;39.1,-49.62,;40.42,-48.85,;41.75,-49.61,;41.75,-51.14,;43.09,-51.91,;43.1,-53.45,;41.76,-54.22,;41.77,-55.76,;43.1,-56.53,;43.11,-58.07,;44.44,-55.74,;44.43,-54.21,;45.76,-53.43,;40.43,-51.91,;39.1,-51.15,;37.77,-51.93,;36.43,-51.16,;36.43,-49.62,;35.1,-48.85,;40.36,-44.1,;41.82,-44.58,;42.73,-43.34,;41.83,-42.09,;42.31,-40.63,;40.36,-42.56,)|
Structure
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