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TargetBeta-lactamase
LigandBDBM21642
Substrate/Competitorn/a
Meas. Tech.ChEMBL_839906 (CHEMBL2090107)
IC50 25800±n/a nM
Citation Chen, PHorton, LBMikulski, RLDeng, LSundriyal, SPalzkill, TSong, Y 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-ß-lactamases. Bioorg Med Chem Lett22:6229-32 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-lactamase
Name:Beta-lactamase
Synonyms:BAS3245 | Beta-lactamase (Bla2) | Beta-lactamase II | GBAA_3500 | bla2
Type:Enzyme
Mol. Mass.:28177.23
Organism:Bacillus anthracis
Description:Q93T40
Residue:256
Sequence:
MKNTLLKLGVCVSLLGITPFVSTISSVQAERKVEHKVIKNETGTISISQLNKNVWVHTEL
GYFNGEAVPSNGLILNTSKGLVLVDSSWDDKLTKELIEMAEKKFKKSVTDVIITHAHADR
IGGIKTLKERGIKAHSTTLTAELAKKNGYEEPLGDLQAITKLKFGNMKVETFYPGKGHTE
DNIVVWLPQYNMLVGGCLVKSASAKDLGNITDAYVNEWSTSIENVLKRYENINFVVPGHG
EVGDKGLLLHTLDLLK
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  Blast E-value cutoff:
BDBM21642
n/a
NameBDBM21642
Synonyms:(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid | CHEMBL1560 | Capozide | Captopril | Lopirin | SQ 14,225 | SQ14534 | US11491146, Compound L-Captopril
TypeSmall organic molecule
Emp. Form.C9H15NO3S
Mol. Mass.217.285
SMILESC[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
Structure
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