| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50421225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_839906 (CHEMBL2090107) |
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| IC50 | >200000±n/a nM |
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| Citation |  Chen, P; Horton, LB; Mikulski, RL; Deng, L; Sundriyal, S; Palzkill, T; Song, Y 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-ß-lactamases. Bioorg Med Chem Lett22:6229-32 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | BAS3245 | Beta-lactamase (Bla2) | Beta-lactamase II | GBAA_3500 | bla2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 28177.23 |
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| Organism: | Bacillus anthracis |
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| Description: | Q93T40 |
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| Residue: | 256 |
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| Sequence: | MKNTLLKLGVCVSLLGITPFVSTISSVQAERKVEHKVIKNETGTISISQLNKNVWVHTEL
GYFNGEAVPSNGLILNTSKGLVLVDSSWDDKLTKELIEMAEKKFKKSVTDVIITHAHADR
IGGIKTLKERGIKAHSTTLTAELAKKNGYEEPLGDLQAITKLKFGNMKVETFYPGKGHTE
DNIVVWLPQYNMLVGGCLVKSASAKDLGNITDAYVNEWSTSIENVLKRYENINFVVPGHG
EVGDKGLLLHTLDLLK
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| BDBM50421225 |
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| n/a |
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| Name | BDBM50421225 |
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| Synonyms: | CHEMBL2087632 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8BrNO2S |
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| Mol. Mass. | 286.145 |
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| SMILES | OC(=O)[C@@H]1CSC(=N1)c1ccc(Br)cc1 |r,c:6| |
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| Structure | 
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