Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M3

Ligand

BDBM50263887

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_937332 (CHEMBL2319366)

EC50

>30000±n/a nM

Citation

Sheffler, DJ; Sevel, C; Le, U; Lovell, KM; Tarr, JC; Carrington, SJ; Cho, HP; Digby, GJ; Niswender, CM; Conn, PJ; Hopkins, CR; Wood, MR; Lindsley, CW Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism. Bioorg Med Chem Lett23:223-7 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M3

Name:

Muscarinic acetylcholine receptor M3

Synonyms:

ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3

Type:

Enzyme Catalytic Domain

Mol. Mass.:

66086.66

Organism:

RAT

Description:

Cholinergic, muscarinic M3 CHRM3 RAT::P08483

Residue:

589

Sequence:

MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVK
RSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSET
RAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQ
KDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRM
SLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNP
VCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL

BDBM50263887

n/a

Name

BDBM50263887

Synonyms:

1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | 1-(1'-2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | CHEMBL522460

Type

Small organic molecule

Emp. Form.

C25H32N4O

Mol. Mass.

404.5478

SMILES

Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O

Structure