| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
|---|
| Ligand | BDBM50424122 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_937329 (CHEMBL2319092) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Sheffler, DJ; Sevel, C; Le, U; Lovell, KM; Tarr, JC; Carrington, SJ; Cho, HP; Digby, GJ; Niswender, CM; Conn, PJ; Hopkins, CR; Wood, MR; Lindsley, CW Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism. Bioorg Med Chem Lett23:223-7 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M2 |
|---|
| Name: | Muscarinic acetylcholine receptor M2 |
|---|
| Synonyms: | ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 51555.53 |
|---|
| Organism: | RAT |
|---|
| Description: | P10980 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
|
|
|
|---|
| BDBM50424122 |
|---|
| n/a |
|---|
| Name | BDBM50424122 |
|---|
| Synonyms: | CHEMBL2315676 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H34N4O |
|---|
| Mol. Mass. | 430.5851 |
|---|
| SMILES | Cc1ccccc1CN1CCC(CC1)N1CC2CC(CC2C1)n1c2ccccc2[nH]c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
