| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50424198 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_933603 (CHEMBL2319987) |
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| IC50 | 127±n/a nM |
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| Citation |  Li, Y; Zhou, Y; Qian, P; Wang, Y; Jiang, F; Yao, Z; Hu, W; Zhao, Y; Li, S Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors. Bioorg Med Chem Lett23:179-82 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50424198 |
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| n/a |
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| Name | BDBM50424198 |
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| Synonyms: | CHEMBL2312458 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N8O |
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| Mol. Mass. | 450.4952 |
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| SMILES | Cc1nc2ncccn2c1-c1ccnc(NCc2ccc(cc2)C(=O)Nc2ccccc2N)n1 |
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| Structure | 
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