| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
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| Ligand | BDBM50424680 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934299 (CHEMBL2320045) |
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| IC50 | 930±n/a nM |
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| Citation |  Loidreau, Y; Marchand, P; Dubouilh-Benard, C; Nourrisson, MR; Duflos, M; Loaëc, N; Meijer, L; Besson, T Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases. Eur J Med Chem59:283-95 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
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| Synonyms: | DYR1A_RAT | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | Dyrk | Dyrk1a |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 85573.59 |
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| Organism: | RAT |
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| Description: | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0 RAT::Q63470 |
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| Residue: | 763 |
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| Sequence: | MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPNISDQQVSALSYSD
QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
HFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
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| BDBM50424680 |
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| n/a |
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| Name | BDBM50424680 |
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| Synonyms: | CHEMBL2313908 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17N3O3S |
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| Mol. Mass. | 367.422 |
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| SMILES | COc1ccc2c(c1)sc1c(Nc3ccc(OC)c(OC)c3)ncnc21 |
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| Structure | 
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