Ki Summary

Reaction Details

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Target

Solute carrier family 22 member 2

Ligand

BDBM50170723

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_934317 (CHEMBL2320303)

IC50

400±n/a nM

Citation

Wittwer, MB; Zur, AA; Khuri, N; Kido, Y; Kosaka, A; Zhang, X; Morrissey, KM; Sali, A; Huang, Y; Giacomini, KM Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem56:781-95 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Solute carrier family 22 member 2

Name:

Solute carrier family 22 member 2

Synonyms:

OCT2 | Organic cation transporter 2 | S22A2_HUMAN | SLC22A2 | hOCT2

Type:

PROTEIN

Mol. Mass.:

62591.01

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1484077

Residue:

555

Sequence:

MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
YQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAM
RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
KMIYLQVQKLDIPLN

BDBM50170723

n/a

Name

BDBM50170723

Synonyms:

1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) | CHEMBL790 | CHLORHEXIDINE | N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] | N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide

Type

Small organic molecule

Emp. Form.

C22H30Cl2N10

Mol. Mass.

505.447

SMILES

NC(NC(N)=Nc1ccc(Cl)cc1)=NCCCCCCN=C(N)N=C(N)Nc1ccc(Cl)cc1 |w:13.14,20.20,23.23,5.5|

Structure