| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier family 22 member 2 |
|---|
| Ligand | BDBM85330 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_934317 (CHEMBL2320303) |
|---|
| IC50 | 1700±n/a nM |
|---|
| Citation |  Wittwer, MB; Zur, AA; Khuri, N; Kido, Y; Kosaka, A; Zhang, X; Morrissey, KM; Sali, A; Huang, Y; Giacomini, KM Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem56:781-95 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier family 22 member 2 |
|---|
| Name: | Solute carrier family 22 member 2 |
|---|
| Synonyms: | OCT2 | Organic cation transporter 2 | S22A2_HUMAN | SLC22A2 | hOCT2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 62591.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1484077 |
|---|
| Residue: | 555 |
|---|
| Sequence: | MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
YQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAM
RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
KMIYLQVQKLDIPLN
|
|
|
|---|
| BDBM85330 |
|---|
| n/a |
|---|
| Name | BDBM85330 |
|---|
| Synonyms: | CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron hydrochloride |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19N3O |
|---|
| Mol. Mass. | 293.363 |
|---|
| SMILES | Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C |
|---|
| Structure | 
|
|---|
Search and Browse
