| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50424791 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934508 (CHEMBL2321455) |
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| IC50 | 2400±n/a nM |
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| Citation |  Zhang, Z; Sun, S; Kodumuru, V; Hou, D; Liu, S; Chakka, N; Sviridov, S; Chowdhury, S; McLaren, DG; Ratkay, LG; Khakh, K; Cheng, X; Gschwend, HW; Kamboj, R; Fu, J; Winther, MD Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome. J Med Chem56:568-83 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50424791 |
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| n/a |
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| Name | BDBM50424791 |
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| Synonyms: | CHEMBL2315093 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27F3N4O2 |
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| Mol. Mass. | 448.4813 |
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| SMILES | CC(C)CCNC(=O)c1ccc(cn1)N1CCN(CC1)C(=O)c1ccccc1C(F)(F)F |
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| Structure | 
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