| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
|---|
| Ligand | BDBM50424822 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_934508 (CHEMBL2321455) |
|---|
| IC50 | 2249±n/a nM |
|---|
| Citation |  Zhang, Z; Sun, S; Kodumuru, V; Hou, D; Liu, S; Chakka, N; Sviridov, S; Chowdhury, S; McLaren, DG; Ratkay, LG; Khakh, K; Cheng, X; Gschwend, HW; Kamboj, R; Fu, J; Winther, MD Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome. J Med Chem56:568-83 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stearoyl-CoA desaturase |
|---|
| Name: | Stearoyl-CoA desaturase |
|---|
| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41537.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00767 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
|
|
|
|---|
| BDBM50424822 |
|---|
| n/a |
|---|
| Name | BDBM50424822 |
|---|
| Synonyms: | CHEMBL2315111 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22F3N7O2 |
|---|
| Mol. Mass. | 485.4617 |
|---|
| SMILES | Cc1cnc(CNC(=O)c2ccc(nn2)N2CCN(CC2)C(=O)c2ccccc2C(F)(F)F)cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
