| Reaction Details |
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 | Report a problem with these data |
| Target | D-beta-D-heptose 7-phosphate kinase |
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| Ligand | BDBM50425039 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_936590 (CHEMBL2318753) |
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| IC50 | 810±n/a nM |
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| Citation |  Lee, TW; Verhey, TB; Antiperovitch, PA; Atamanyuk, D; Desroy, N; Oliveira, C; Denis, A; Gerusz, V; Drocourt, E; Loutet, SA; Hamad, MA; Stanetty, C; Andres, SN; Sugiman-Marangos, S; Kosma, P; Valvano, MA; Moreau, F; Junop, MS Structural-functional studies of Burkholderia cenocepacia D-glycero-ß-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties. J Med Chem56:1405-17 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D-beta-D-heptose 7-phosphate kinase |
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| Name: | D-beta-D-heptose 7-phosphate kinase |
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| Synonyms: | hldA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33999.14 |
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| Organism: | Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderiacenocepacia (strain J2315)) |
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| Description: | ChEMBL_936590 |
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| Residue: | 316 |
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| Sequence: | MNTLREVVPVPREQLARSRVLVVGDVMLDRYWFGNVDRISPEAPVPVVHVQRQEERLGGA
ANVARNAVTLGGQAGLLCVVGCDEPGERIVELLGSSGVTPHLERDPALPTTIKLRVLARQ
QQLLRVDFEAMPTHEVLLAGLARFDVLLPQHDVVLMSDYAKGGLTHVTTMIEKARAAGKA
VLVDPKGDDWARYRGASLITPNRAELREVVGQWKSEDDLRARVANLRAELDIDALLLTRS
EEGMTLFSAGGELHAPALAREVFDVSGAGDTVIATVATMLGAGVPLVDAVVLANRAAGIV
VGKLGTATVDYDELFH
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| BDBM50425039 |
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| n/a |
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| Name | BDBM50425039 |
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| Synonyms: | CHEMBL2312559 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N5O5S |
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| Mol. Mass. | 453.471 |
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| SMILES | COc1cccc(OC)c1-c1cnnc(NCc2nc3cc(OCC(O)=O)ccc3s2)n1 |
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| Structure | 
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