Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50425150 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_936852 (CHEMBL2320734) |
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IC50 | 1120±n/a nM |
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Citation | Eccles, W; Blevitt, JM; Booker, JN; Chrovian, CC; Crawford, S; de Leon, AR; Deng, X; Fourie, AM; Grice, CA; Herman, K; Karlsson, L; Kearney, AM; Lee-Dutra, A; Liang, J; Luna, R; Pippel, D; Rao, N; Riley, JP; Santillán, A; Savall, B; Tanis, VM; Xue, X; Young, AL Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase. Bioorg Med Chem Lett23:811-5 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_MOUSE | Leukotriene A4 hydrolase | Lta4h |
Type: | PROTEIN |
Mol. Mass.: | 69048.58 |
Organism: | Mus musculus |
Description: | ChEMBL_936852 |
Residue: | 611 |
Sequence: | MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDL
TIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAP
DPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGES
HPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSV
TTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAK
EEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVT
AMLVGRDLKVD
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BDBM50425150 |
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n/a |
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Name | BDBM50425150 |
Synonyms: | CHEMBL2313564 |
Type | Small organic molecule |
Emp. Form. | C20H18N2O3S |
Mol. Mass. | 366.434 |
SMILES | C(N1CCOCC1)c1coc2cc(Oc3nc4ccccc4s3)ccc12 |
Structure |
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