Reaction Details |
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Target | Threonine--tRNA ligase |
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Ligand | BDBM50426193 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_935847 (CHEMBL2317883) |
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Ki | 23±n/a nM |
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Citation | Teng, M; Hilgers, MT; Cunningham, ML; Borchardt, A; Locke, JB; Abraham, S; Haley, G; Kwan, BP; Hall, C; Hough, GW; Shaw, KJ; Finn, J Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J Med Chem56:1748-60 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Threonine--tRNA ligase |
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Name: | Threonine--tRNA ligase |
Synonyms: | SYT_YERPE | ThrRS | YP_2221 | thrS | y1903 |
Type: | PROTEIN |
Mol. Mass.: | 73649.43 |
Organism: | Yersinia pestis |
Description: | ChEMBL_935847 |
Residue: | 642 |
Sequence: | MPVITLPDGSQRHYDHAVSVLDVALDIGPGLAKACIAGRVNGELVDASDLIESDAQLAII
TAKDAEGLEILRHSCAHLLGHAIKQLWPDTKMAIGPVIDNGFYYDVDIEHTLTQEDLALL
EKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILDENISRDDRPGLYHHEEYVD
MCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWGDKKQLNAYLQRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFVRMKLKEYQYQEVKGPFMMD
RVLWEKTGHWENYAEHMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGS
CHRNEPSGALHGLMRVRGFTQDDAHVFCTEEQVRDEVNSCIKMVYDMYSTFGFEKIVVKL
STRPEKRIGSDELWTRAEDDLAAALTENGIPFDYQPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDFSLPGRLSASYIGENNDRQVPVMIHRAILGSMERFIGILTEEYAGFFPTWLAPV
QVVVMNITDSQSDYVQQVTKKLQDAGIRAKADLRNEKIGFKIREHTLRRVPYMLVCGDKE
VESGKIAVRTRRGKDLGSLDVNVVVDQLLAEIRSRSLHQLEE
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BDBM50426193 |
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n/a |
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Name | BDBM50426193 |
Synonyms: | CHEMBL2316967 |
Type | Small organic molecule |
Emp. Form. | C18H23N5O4S |
Mol. Mass. | 405.471 |
SMILES | CC(C)[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)\C=C\c1cccc(c1)-c1cc(N)ncn1 |r| |
Structure |
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