Reaction Details |
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Target | Sodium- and chloride-dependent glycine transporter 2 |
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Ligand | BDBM50427191 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_938180 (CHEMBL2328381) |
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IC50 | >75000±n/a nM |
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Citation | Cioffi, CL; Wolf, MA; Guzzo, PR; Sadalapure, K; Parthasarathy, V; Dethe, D; Maeng, JH; Carulli, E; Loong, DT; Fang, X; Hu, M; Gupta, P; Chung, M; Bai, M; Moore, N; Luche, M; Khmelnitsky, Y; Love, PL; Watson, MA; Mhyre, AJ; Liu, S Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1. Bioorg Med Chem Lett23:1257-61 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent glycine transporter 2 |
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Name: | Sodium- and chloride-dependent glycine transporter 2 |
Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 87438.56 |
Organism: | Homo sapiens (Human) |
Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
Residue: | 797 |
Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
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BDBM50427191 |
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n/a |
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Name | BDBM50427191 |
Synonyms: | CHEMBL2324165 |
Type | Small organic molecule |
Emp. Form. | C22H31ClF3N3O3S |
Mol. Mass. | 510.013 |
SMILES | CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2cccc(c2Cl)C(F)(F)F)CCCCC1 |
Structure |
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