Reaction Details |
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Target | RAC-beta serine/threonine-protein kinase |
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Ligand | BDBM50427344 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_941088 (CHEMBL2330885) |
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IC50 | 210±n/a nM |
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Citation | Addie, M; Ballard, P; Buttar, D; Crafter, C; Currie, G; Davies, BR; Debreczeni, J; Dry, H; Dudley, P; Greenwood, R; Johnson, PD; Kettle, JG; Lane, C; Lamont, G; Leach, A; Luke, RW; Morris, J; Ogilvie, D; Page, K; Pass, M; Pearson, S; Ruston, L Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. J Med Chem56:2059-73 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAC-beta serine/threonine-protein kinase |
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Name: | RAC-beta serine/threonine-protein kinase |
Synonyms: | AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta |
Type: | Enzyme |
Mol. Mass.: | 55766.64 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 481 |
Sequence: | MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
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BDBM50427344 |
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n/a |
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Name | BDBM50427344 |
Synonyms: | CHEMBL2325984 | US10654855, Example 29 | US11236095, Example 29 | US9492453, 29 |
Type | Small organic molecule |
Emp. Form. | C25H25ClN6O |
Mol. Mass. | 460.959 |
SMILES | NC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)NC(c1ccccc1)c1ccc(Cl)cc1 |
Structure |
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