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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | WD repeat-containing protein 5 | ||
| Ligand | BDBM50428255 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_946434 (CHEMBL2339614) | ||
| IC50 | 6000±n/a nM | ||
| Citation |  Bolshan, Y; Getlik, M; Kuznetsova, E; Wasney, GA; Hajian, T; Poda, G; Nguyen, KT; Wu, H; Dombrovski, L; Dong, A; Senisterra, G; Schapira, M; Arrowsmith, CH; Brown, PJ; Al-Awar, R; Vedadi, M; Smil, D Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett4:353-7 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| WD repeat-containing protein 5 | |||
| Name: | WD repeat-containing protein 5 | ||
| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 36597.13 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P61964 | ||
| Residue: | 334 | ||
| Sequence: |
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| BDBM50428255 | |||
| n/a | |||
| Name | BDBM50428255 | ||
| Synonyms: | CHEMBL1231559 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H14O4 | ||
| Mol. Mass. | 342.3442 | ||
| SMILES | OC(=O)c1ccc2ccccc2c1-c1c(ccc2ccccc12)C(O)=O |(-4.26,1.44,;-3.56,.84,;-3.56,-.7,;-1.59,1.44,;-1.59,2.98,;-.26,3.75,;1.07,2.98,;2.41,3.75,;3.74,2.98,;3.74,1.44,;2.41,.67,;1.07,1.44,;-.26,.67,;-.26,-.87,;-1.59,-1.64,;-1.59,-3.18,;-.26,-3.95,;1.07,-3.18,;2.41,-3.95,;3.74,-3.18,;3.74,-1.64,;2.41,-.87,;1.07,-1.64,;-2.93,-.87,;-4.26,-1.64,;-2.93,.67,)| | ||
| Structure | 
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