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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Retinoic acid receptor RXR-alpha | ||
| Ligand | BDBM50429864 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_942867 (CHEMBL2342375) | ||
| EC50 | 155±n/a nM | ||
| Citation |  Ohsawa, F; Yamada, S; Yakushiji, N; Shinozaki, R; Nakayama, M; Kawata, K; Hagaya, M; Kobayashi, T; Kohara, K; Furusawa, Y; Fujiwara, C; Ohta, Y; Makishima, M; Naitou, H; Tai, A; Yoshikawa, Y; Yasui, H; Kakuta, H Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency. J Med Chem56:1865-77 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Retinoic acid receptor RXR-alpha | |||
| Name: | Retinoic acid receptor RXR-alpha | ||
| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50820.38 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1456363 | ||
| Residue: | 462 | ||
| Sequence: |
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| BDBM50429864 | |||
| n/a | |||
| Name | BDBM50429864 | ||
| Synonyms: | CHEMBL2332886 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H27N3O2 | ||
| Mol. Mass. | 377.4794 | ||
| SMILES | Cc1cc2c(cc1-n1c(N)nc3cc(ccc13)C(O)=O)C(C)(C)CCC2(C)C |(24.03,-22.65,;22.68,-21.9,;21.37,-22.7,;20.02,-21.95,;19.98,-20.42,;21.31,-19.62,;22.65,-20.36,;23.97,-19.57,;25.39,-20.16,;25.73,-21.66,;26.39,-19,;25.6,-17.68,;26.04,-16.21,;24.99,-15.09,;23.49,-15.43,;23.05,-16.91,;24.1,-18.03,;25.44,-13.61,;26.94,-13.26,;24.38,-12.48,;18.66,-19.65,;17.6,-18.53,;19.6,-18.48,;17.32,-20.47,;17.35,-22.01,;18.68,-22.77,;19.73,-23.89,;17.73,-23.95,)| | ||
| Structure | 
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