| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
|---|
| Ligand | BDBM50391814 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_942867 (CHEMBL2342375) |
|---|
| EC50 | 143±n/a nM |
|---|
| Citation |  Ohsawa, F; Yamada, S; Yakushiji, N; Shinozaki, R; Nakayama, M; Kawata, K; Hagaya, M; Kobayashi, T; Kohara, K; Furusawa, Y; Fujiwara, C; Ohta, Y; Makishima, M; Naitou, H; Tai, A; Yoshikawa, Y; Yasui, H; Kakuta, H Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency. J Med Chem56:1865-77 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoic acid receptor RXR-alpha |
|---|
| Name: | Retinoic acid receptor RXR-alpha |
|---|
| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50820.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1456363 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
|
|
|
|---|
| BDBM50391814 |
|---|
| n/a |
|---|
| Name | BDBM50391814 |
|---|
| Synonyms: | CHEMBL2146901 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25N3O2 |
|---|
| Mol. Mass. | 363.4528 |
|---|
| SMILES | Cc1cc2c(cc1-n1nnc3cc(ccc13)C(O)=O)C(C)(C)CCC2(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
