Ki Summary

Reaction Details

Report a problem with these data

Target

Retinoic acid receptor RXR-alpha

Ligand

BDBM50429866

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_942867 (CHEMBL2342375)

EC50

15±n/a nM

Citation

Ohsawa, F; Yamada, S; Yakushiji, N; Shinozaki, R; Nakayama, M; Kawata, K; Hagaya, M; Kobayashi, T; Kohara, K; Furusawa, Y; Fujiwara, C; Ohta, Y; Makishima, M; Naitou, H; Tai, A; Yoshikawa, Y; Yasui, H; Kakuta, H Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency. J Med Chem56:1865-77 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Retinoic acid receptor RXR-alpha

Name:

Retinoic acid receptor RXR-alpha

Synonyms:

Type:

PROTEIN

Mol. Mass.:

50820.38

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1456363

Residue:

462

Sequence:

MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT

BDBM50429866

n/a

Name

BDBM50429866

Synonyms:

CHEMBL2332887

Type

Small organic molecule

Emp. Form.

C24H25F3N2O2

Mol. Mass.

430.4627

SMILES

Cc1cc2c(cc1-n1c(nc3cc(ccc13)C(O)=O)C(F)(F)F)C(C)(C)CCC2(C)C |(23.28,-13.29,;21.95,-14.06,;20.61,-13.28,;19.28,-14.05,;19.28,-15.59,;20.6,-16.36,;21.94,-15.6,;23.27,-16.37,;23.43,-17.9,;24.94,-18.23,;25.71,-16.9,;27.22,-16.58,;27.7,-15.12,;26.67,-13.97,;25.17,-14.29,;24.69,-15.75,;29.21,-14.81,;30.24,-15.95,;29.69,-13.33,;22.29,-18.93,;20.84,-18.45,;22.61,-20.43,;21.2,-20.01,;17.92,-16.37,;16.94,-17.54,;18.94,-17.52,;16.61,-15.59,;16.6,-14.04,;17.96,-13.26,;18.94,-12.09,;16.93,-12.11,)|

Structure