Reaction Details |
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Target | Acid ceramidase |
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Ligand | BDBM50431260 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_949261 (CHEMBL2346137) |
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IC50 | 13±n/a nM |
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Citation | Pizzirani, D; Pagliuca, C; Realini, N; Branduardi, D; Bottegoni, G; Mor, M; Bertozzi, F; Scarpelli, R; Piomelli, D; Bandiera, T Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem56:3518-30 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acid ceramidase |
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Name: | Acid ceramidase |
Synonyms: | AC | ACDase | ASAH1_RAT | Acid CDase | Acid ceramidase | Acid ceramidase (AC) | Acylsphingosine deacylase | Asah1 | N-acylsphingosine amidohydrolase |
Type: | Enzyme |
Mol. Mass.: | 44450.22 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q6P7S1 |
Residue: | 394 |
Sequence: | MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKR
WHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIAD
VTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEE
LKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMF
GKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKES
LDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTK
PVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
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BDBM50431260 |
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n/a |
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Name | BDBM50431260 |
Synonyms: | CHEMBL2333048 |
Type | Small organic molecule |
Emp. Form. | C12H18FN3O3 |
Mol. Mass. | 271.288 |
SMILES | CCCCCCNC(=O)n1cc(F)c(=O)n(C)c1=O |
Structure |
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