| Reaction Details |
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 | Report a problem with these data |
| Target | Acid ceramidase |
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| Ligand | BDBM50431273 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_949261 (CHEMBL2346137) |
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| IC50 | 1460±n/a nM |
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| Citation |  Pizzirani, D; Pagliuca, C; Realini, N; Branduardi, D; Bottegoni, G; Mor, M; Bertozzi, F; Scarpelli, R; Piomelli, D; Bandiera, T Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem56:3518-30 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acid ceramidase |
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| Name: | Acid ceramidase |
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| Synonyms: | AC | ACDase | ASAH1_RAT | Acid CDase | Acid ceramidase | Acid ceramidase (AC) | Acylsphingosine deacylase | Asah1 | N-acylsphingosine amidohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 44450.22 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q6P7S1 |
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| Residue: | 394 |
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| Sequence: | MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKR
WHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIAD
VTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEE
LKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMF
GKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKES
LDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTK
PVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
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| BDBM50431273 |
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| n/a |
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| Name | BDBM50431273 |
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| Synonyms: | CHEMBL2333031 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H19N3O3 |
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| Mol. Mass. | 253.2976 |
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| SMILES | CCCCCCNC(=O)n1cc(C)c(=O)[nH]c1=O |
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| Structure | 
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