Reaction Details |
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Target | Beta-secretase 1 |
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Ligand | BDBM50432506 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_954243 (CHEMBL2352293) |
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IC50 | 24±n/a nM |
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Citation | Hunt, KW; Cook, AW; Watts, RJ; Clark, CT; Vigers, G; Smith, D; Metcalf, AT; Gunawardana, IW; Burkard, M; Cox, AA; Geck Do, MK; Dutcher, D; Thomas, AA; Rana, S; Kallan, NC; DeLisle, RK; Rizzi, JP; Regal, K; Sammond, D; Groneberg, R; Siu, M; Purkey, H; Lyssikatos, JP; Marlow, A; Liu, X; Tang, TP Spirocyclicß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloidß in a higher species. J Med Chem56:3379-403 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 1 |
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Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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BDBM50432506 |
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n/a |
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Name | BDBM50432506 |
Synonyms: | CHEMBL2349612 |
Type | Small organic molecule |
Emp. Form. | C20H20ClN3O2 |
Mol. Mass. | 369.845 |
SMILES | CN1C(N)=NC2(CC(C)(C)Oc3ccc(cc23)-c2cccc(Cl)c2)C1=O |c:3| |
Structure |
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