| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D-amino-acid oxidase |
|---|
| Ligand | BDBM50433371 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_957000 (CHEMBL2378382) |
|---|
| Ki | 190±n/a nM |
|---|
| Citation |  Hopkins, SC; Heffernan, ML; Saraswat, LD; Bowen, CA; Melnick, L; Hardy, LW; Orsini, MA; Allen, MS; Koch, P; Spear, KL; Foglesong, RJ; Soukri, M; Chytil, M; Fang, QK; Jones, SW; Varney, MA; Panatier, A; Oliet, SH; Pollegioni, L; Piubelli, L; Molla, G; Nardini, M; Large, TH Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules. J Med Chem56:3710-24 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D-amino-acid oxidase |
|---|
| Name: | D-amino-acid oxidase |
|---|
| Synonyms: | D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN |
|---|
| Type: | Homodimer |
|---|
| Mol. Mass.: | 39476.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14920 |
|---|
| Residue: | 347 |
|---|
| Sequence: | MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPN
NPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPR
ELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVN
CTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGG
IFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
|
|
|
|---|
| BDBM50433371 |
|---|
| n/a |
|---|
| Name | BDBM50433371 |
|---|
| Synonyms: | CHEMBL2375519 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13NO3 |
|---|
| Mol. Mass. | 255.2686 |
|---|
| SMILES | OC(=O)c1cc2occ(CCc3ccccc3)c2[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
