Reaction Details |
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Target | Muscarinic acetylcholine receptor M5 |
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Ligand | BDBM50433574 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_960031 (CHEMBL2384201) |
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EC50 | 4.6±n/a nM |
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Citation | Gentry, PR; Bridges, TM; Lamsal, A; Vinson, PN; Smith, E; Chase, P; Hodder, PS; Engers, JL; Niswender, CM; Daniels, JS; Jeffrey Conn, P; Wood, MR; Lindsley, CW Discovery of ML326: The first sub-micromolar, selective M5 PAM. Bioorg Med Chem Lett23:2996-3000 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M5 |
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Name: | Muscarinic acetylcholine receptor M5 |
Synonyms: | ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 60161.80 |
Organism: | RAT |
Description: | Cholinergic, muscarinic M5 CHRM5 RAT::P08911 |
Residue: | 531 |
Sequence: | MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQL
KTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNL
LVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPD
ECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKK
REPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVT
TCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKY
FLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPN
LSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGY
WLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
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BDBM50433574 |
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n/a |
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Name | BDBM50433574 |
Synonyms: | CHEMBL2381694 |
Type | Small organic molecule |
Emp. Form. | C17H12F3NO4 |
Mol. Mass. | 351.2767 |
SMILES | FC(F)(F)Oc1ccc2N(CCOc3ccccc3)C(=O)C(=O)c2c1 |
Structure |
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