| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase SIK1 |
|---|
| Ligand | BDBM50433629 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_959021 (CHEMBL2382834) |
|---|
| IC50 | 211±n/a nM |
|---|
| Citation |  Karra, S; Xiao, Y; Chen, X; Liu-Bujalski, L; Huck, B; Sutton, A; Goutopoulos, A; Askew, B; Josephson, K; Jiang, X; Shutes, A; Shankar, V; Noonan, T; Garcia-Berrios, G; Dong, R; Dhanabal, M; Tian, H; Wang, Z; Clark, A; Goodstal, S SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg Med Chem Lett23:3081-7 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase SIK1 |
|---|
| Name: | Serine/threonine-protein kinase SIK1 |
|---|
| Synonyms: | SIK | SIK1 | SIK1_HUMAN | SNF1LK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 84908.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774213 |
|---|
| Residue: | 783 |
|---|
| Sequence: | MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDK
TRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH
LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPL
STWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGR
FRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSN
LGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPAR
QPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFP
VDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTR
LSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLAS
PFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFL
GLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRL
LQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASP
VASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFV
LVQ
|
|
|
|---|
| BDBM50433629 |
|---|
| n/a |
|---|
| Name | BDBM50433629 |
|---|
| Synonyms: | CHEMBL2380845 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H18N4O2 |
|---|
| Mol. Mass. | 406.436 |
|---|
| SMILES | O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
