| Reaction Details |
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 | Report a problem with these data |
| Target | Chymase |
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| Ligand | BDBM50434109 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_958460 (CHEMBL2383101) |
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| IC50 | 40±n/a nM |
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| Citation |  Taylor, SJ; Padyana, AK; Abeywardane, A; Liang, S; Hao, MH; De Lombaert, S; Proudfoot, J; Farmer, BS; Li, X; Collins, B; Martin, L; Albaugh, DR; Hill-Drzewi, M; Pullen, SS; Takahashi, H Discovery of potent, selective chymase inhibitors via fragment linking strategies. J Med Chem56:4465-81 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chymase |
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| Name: | Chymase |
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| Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
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| Type: | Enzyme |
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| Mol. Mass.: | 27340.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 247 |
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| Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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| BDBM50434109 |
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| n/a |
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| Name | BDBM50434109 |
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| Synonyms: | CHEMBL2381483 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22BrN3O4 |
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| Mol. Mass. | 472.332 |
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| SMILES | CCCC(CC(O)=O)n1c2ccccc2n(Cc2cc(Br)cc3NC(=O)Cc23)c1=O |
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| Structure | 
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