| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP6 |
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| Ligand | BDBM50434157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_959426 (CHEMBL2384338) |
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| IC50 | >10000±n/a nM |
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| Citation |  Bregman, H; Chakka, N; Guzman-Perez, A; Gunaydin, H; Gu, Y; Huang, X; Berry, V; Liu, J; Teffera, Y; Huang, L; Egge, B; Mullady, EL; Schneider, S; Andrews, PS; Mishra, A; Newcomb, J; Serafino, R; Strathdee, CA; Turci, SM; Wilson, C; DiMauro, EF Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors. J Med Chem56:4320-42 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP6 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP6 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 17 | ARTD17 | PARP-6 | PARP6 | PARP6_HUMAN | Poly [ADP-ribose] polymerase 6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71130.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107589 |
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| Residue: | 630 |
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| Sequence: | MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIRE
YGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSN
KEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPI
PKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQH
VGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSM
LKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPS
VVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQW
IISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENW
HSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYN
RMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYED
GQVGDANINTQDPKIQKEIMRVIGTQVYTN
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| BDBM50434157 |
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| n/a |
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| Name | BDBM50434157 |
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| Synonyms: | CHEMBL2381958 | US9340549, 78 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23N3O3 |
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| Mol. Mass. | 437.4898 |
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| SMILES | CC1(C)OC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)C(=O)Nc1cccc2cccnc12 |r| |
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| Structure | 
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