| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 1 |
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| Ligand | BDBM50436640 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_967619 (CHEMBL2399239) |
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| IC50 | >100000±n/a nM |
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| Citation |  Sleebs, BE; Kersten, WJ; Kulasegaram, S; Nikolakopoulos, G; Hatzis, E; Moss, RM; Parisot, JP; Yang, H; Czabotar, PE; Fairlie, WD; Lee, EF; Adams, JM; Chen, L; van Delft, MF; Lowes, KN; Wei, A; Huang, DC; Colman, PM; Street, IP; Baell, JB; Watson, K; Lessene, G Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem56:5514-40 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 1 |
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| Name: | Bcl-2-like protein 1 |
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| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
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| Type: | Mitochondrion membrane; Single-pass membrane protein |
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| Mol. Mass.: | 26039.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM50436640 |
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| n/a |
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| Name | BDBM50436640 |
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| Synonyms: | CHEMBL2398293 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15N3O3S |
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| Mol. Mass. | 377.416 |
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| SMILES | CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1ccc(cc1)C(O)=O |w:3.3| |
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| Structure | 
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