Reaction Details | |||
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Target | E3 ubiquitin-protein ligase Mdm2 | ||
Ligand | BDBM50436687 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_967970 (CHEMBL2401074) | ||
Ki | 1.1±n/a nM | ||
Citation | Zhao, Y; Yu, S; Sun, W; Liu, L; Lu, J; McEachern, D; Shargary, S; Bernard, D; Li, X; Zhao, T; Zou, P; Sun, D; Wang, S A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. J Med Chem56:5553-61 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
E3 ubiquitin-protein ligase Mdm2 | |||
Name: | E3 ubiquitin-protein ligase Mdm2 | ||
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 55196.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00987 | ||
Residue: | 491 | ||
Sequence: |
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BDBM50436687 | |||
n/a | |||
Name | BDBM50436687 | ||
Synonyms: | CHEMBL2398474 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H30Cl2FN3O3 | ||
Mol. Mass. | 534.45 | ||
SMILES | CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@@H]1C[C@H](O)C1 |r,wU:17.19,8.8,31.34,5.4,33.37,wD:7.31,(13.04,-18.98,;11.84,-18.02,;12.07,-16.5,;13.31,-17.62,;10.4,-18.58,;9.2,-17.61,;9.28,-16.08,;7.83,-15.53,;6.87,-16.73,;5.53,-15.96,;4.2,-16.73,;2.86,-15.97,;2.85,-14.41,;4.19,-13.64,;4.19,-12.1,;5.53,-14.41,;5.52,-12.86,;7.72,-18.02,;8.63,-19.28,;10.17,-19.28,;7.71,-20.53,;6.24,-20.05,;4.91,-20.82,;3.57,-20.05,;2.24,-20.82,;3.57,-18.51,;4.9,-17.74,;6.24,-18.5,;7.84,-13.99,;6.51,-13.22,;9.18,-13.22,;10.51,-14,;10.89,-15.5,;12.38,-15.1,;13.71,-15.88,;11.99,-13.62,)| | ||
Structure |