Reaction Details |
| Report a problem with these data |
Target | Proto-oncogene tyrosine-protein kinase Src |
---|
Ligand | BDBM92348 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_970148 (CHEMBL2406233) |
---|
IC50 | 1.1±n/a nM |
---|
Citation | Richters, A; Ketzer, J; Getlik, M; Grütter, C; Schneider, R; Heuckmann, JM; Heynck, S; Sos, ML; Gupta, A; Unger, A; Schultz-Fademrecht, C; Thomas, RK; Bauer, S; Rauh, D Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design. J Med Chem56:5757-72 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Proto-oncogene tyrosine-protein kinase Src |
---|
Name: | Proto-oncogene tyrosine-protein kinase Src |
Synonyms: | Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src |
Type: | Tyr protein kinase |
Mol. Mass.: | 60015.36 |
Organism: | Gallus gallus (Chicken) |
Description: | P00523 |
Residue: | 533 |
Sequence: | MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKL
FGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWL
AHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETT
KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHR
LTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG
TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRL
PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ
GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR
MPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
|
|
|
BDBM92348 |
---|
n/a |
---|
Name | BDBM92348 |
Synonyms: | 1,4-Hybrid, 6 |
Type | Small organic molecule |
Emp. Form. | C34H40N10O2 |
Mol. Mass. | 620.7472 |
SMILES | CN(C)CCCC(=O)Nc1ccc2ncnc(Nc3ccc(NC(=O)Nc4cc(nn4-c4cccc(N)c4)C(C)(C)C)cc3)c2c1 |
Structure |
|