Reaction Details | |||
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Target | Insulin-like growth factor 1 receptor | ||
Ligand | BDBM50437368 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_972567 (CHEMBL2410389) | ||
IC50 | 10.0±n/a nM | ||
Citation | Jin, M; Petronella, BA; Cooke, A; Kadalbajoo, M; Siu, KW; Kleinberg, A; May, EW; Gokhale, PC; Schulz, R; Kahler, J; Bittner, MA; Foreman, K; Pachter, JA; Wild, R; Epstein, D; Mulvihill, MJ Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics. ACS Med Chem Lett4:627-31 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Insulin-like growth factor 1 receptor | |||
Name: | Insulin-like growth factor 1 receptor | ||
Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
Type: | Protein | ||
Mol. Mass.: | 154776.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08069 | ||
Residue: | 1367 | ||
Sequence: |
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BDBM50437368 | |||
n/a | |||
Name | BDBM50437368 | ||
Synonyms: | CHEMBL3037914 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H28FN5O2 | ||
Mol. Mass. | 497.5633 | ||
SMILES | CC(C)Oc1cc(nc2c(F)c(ccc12)-c1nc([C@H]2C[C@@](C)(O)C2)n2ccnc(N)c12)-c1ccccc1 |r,wU:20.23,18.19,wD:20.22,(3.2,-17.1,;1.87,-17.87,;.53,-17.1,;1.87,-19.41,;3.21,-20.18,;4.54,-19.41,;5.87,-20.17,;5.88,-21.73,;4.54,-22.5,;4.54,-24.03,;5.88,-24.8,;3.22,-24.81,;1.87,-24.04,;1.87,-22.5,;3.2,-21.73,;3.23,-26.35,;4.48,-27.25,;4.01,-28.72,;4.92,-29.96,;6.44,-30.19,;6.21,-31.71,;7.69,-32.11,;6.61,-33.2,;4.69,-31.48,;2.47,-28.73,;1.45,-29.87,;-.07,-29.55,;-.54,-28.09,;.5,-26.95,;.02,-25.48,;1.99,-27.26,;7.2,-19.4,;8.54,-20.17,;9.87,-19.39,;9.86,-17.85,;8.52,-17.09,;7.19,-17.87,)| | ||
Structure |