Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50438082 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_972969 (CHEMBL2412207) |
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IC50 | 400±n/a nM |
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Citation | Böhme, T; Engel, CK; Farjot, G; Güssregen, S; Haack, T; Tschank, G; Ritter, K 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes. Bioorg Med Chem Lett23:4685-91 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 |
Type: | Enzyme |
Mol. Mass.: | 32369.70 |
Organism: | Mus musculus (mouse) |
Description: | P50172 |
Residue: | 292 |
Sequence: | MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
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BDBM50438082 |
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n/a |
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Name | BDBM50438082 |
Synonyms: | CHEMBL2409756 |
Type | Small organic molecule |
Emp. Form. | C17H26N2O4S |
Mol. Mass. | 354.464 |
SMILES | OC12CC3CC(C1)CC(C3)(C2)N=C1NS(=O)(=O)[C@@H]2CCCC[C@@H]2O1 |r,w:11.13,THB:10:1:4:9.8.7,10:8:2.1.6:4,0:1:4:9.8.7,7:8:2:6.5.4,7:5:2:9.10.8,TEB:11:8:2:6.5.4,11:8:2.1.6:4| |
Structure |
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