Reaction Details |
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Target | Nicotinamide phosphoribosyltransferase |
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Ligand | BDBM50438986 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_977567 (CHEMBL2423349) |
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IC50 | 20±n/a nM |
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Citation | Dragovich, PS; Bair, KW; Baumeister, T; Ho, YC; Liederer, BM; Liu, X; Liu, Y; O'Brien, T; Oeh, J; Sampath, D; Skelton, N; Wang, L; Wang, W; Wu, H; Xiao, Y; Yuen, PW; Zak, M; Zhang, L; Zheng, X Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett23:4875-85 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nicotinamide phosphoribosyltransferase |
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Name: | Nicotinamide phosphoribosyltransferase |
Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
Type: | Enzyme |
Mol. Mass.: | 55524.98 |
Organism: | Homo sapiens (Human) |
Description: | P43490 |
Residue: | 491 |
Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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BDBM50438986 |
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n/a |
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Name | BDBM50438986 |
Synonyms: | CHEMBL2419503 |
Type | Small organic molecule |
Emp. Form. | C21H17N3O3S |
Mol. Mass. | 391.443 |
SMILES | O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1cc2cnccc2[nH]1 |
Structure |
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