Ki Summary

Reaction Details

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Target

Microtubule-associated serine/threonine-protein kinase 3

Ligand

BDBM50439425

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_980178 (CHEMBL2424216)

IC50

740±n/a nM

Citation

Li, B; Cociorva, OM; Nomanbhoy, T; Weissig, H; Li, Q; Nakamura, K; Liyanage, M; Zhang, MC; Shih, AY; Aban, A; Hu, Y; Cajica, J; Pham, L; Kozarich, JW; Shreder, KR Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors. Bioorg Med Chem Lett23:5217-22 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Microtubule-associated serine/threonine-protein kinase 3

Name:

Microtubule-associated serine/threonine-protein kinase 3

Synonyms:

KIAA0561 | MAST3 | MAST3_HUMAN

Type:

PROTEIN

Mol. Mass.:

143157.77

Organism:

Homo sapiens (Human)

Description:

ChEMBL_107645

Residue:

1309

Sequence:

MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLD
SPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQP
TPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERF
PKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFL
EMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAA
EGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRR
KPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILT
FAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEY
LHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQV
CGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWP
EGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLE
AEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTP
TFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQPERGPSPSLLNT
ISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAALSH
ARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSASVS
ALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKY
GFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVV
ELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKKIS
KQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSA
SPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPR
SPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERR
DSFKKQEAVQEVSFDEPQEEATGLPTSVPQIAVEGEEAVPVALGPTGRD

BDBM50439425

n/a

Name

BDBM50439425

Synonyms:

CHEMBL2420555

Type

Small organic molecule

Emp. Form.

C26H26FN5O2

Mol. Mass.

459.5153

SMILES

O[C@H]1CC[C@@H](CC1)Nc1nc2ccc(cc2n2ccnc12)C(=O)NC1(CC1)c1ccc(F)cc1 |r,wU:4.7,wD:1.0,(5.97,-27.29,;7.31,-28.06,;7.31,-29.6,;8.64,-30.37,;9.97,-29.6,;9.97,-28.06,;8.64,-27.29,;11.31,-30.37,;12.64,-29.6,;13.97,-30.37,;15.31,-29.6,;16.64,-30.37,;17.98,-29.6,;17.98,-28.06,;16.64,-27.29,;15.31,-28.06,;13.97,-27.29,;13.65,-25.78,;12.12,-25.62,;11.5,-27.03,;12.64,-28.06,;19.31,-27.29,;19.31,-25.75,;20.64,-28.06,;21.98,-27.29,;22.97,-26.11,;21.45,-25.84,;23.24,-28.17,;23.1,-29.7,;24.37,-30.59,;25.76,-29.94,;27.02,-30.82,;25.89,-28.4,;24.63,-27.52,)|

Structure