Ki Summary

Reaction Details

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Target

Microtubule-associated serine/threonine-protein kinase 3

Ligand

BDBM50439429

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_980178 (CHEMBL2424216)

IC50

1400±n/a nM

Citation

Li, B; Cociorva, OM; Nomanbhoy, T; Weissig, H; Li, Q; Nakamura, K; Liyanage, M; Zhang, MC; Shih, AY; Aban, A; Hu, Y; Cajica, J; Pham, L; Kozarich, JW; Shreder, KR Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors. Bioorg Med Chem Lett23:5217-22 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Microtubule-associated serine/threonine-protein kinase 3

Name:

Microtubule-associated serine/threonine-protein kinase 3

Synonyms:

KIAA0561 | MAST3 | MAST3_HUMAN

Type:

PROTEIN

Mol. Mass.:

143157.77

Organism:

Homo sapiens (Human)

Description:

ChEMBL_107645

Residue:

1309

Sequence:

MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLD
SPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQP
TPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERF
PKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFL
EMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAA
EGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRR
KPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILT
FAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEY
LHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQV
CGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWP
EGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLE
AEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTP
TFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQPERGPSPSLLNT
ISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAALSH
ARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSASVS
ALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKY
GFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVV
ELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKKIS
KQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSA
SPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPR
SPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERR
DSFKKQEAVQEVSFDEPQEEATGLPTSVPQIAVEGEEAVPVALGPTGRD

BDBM50439429

n/a

Name

BDBM50439429

Synonyms:

CHEMBL2420562

Type

Small organic molecule

Emp. Form.

C26H29N5O2

Mol. Mass.

443.5408

SMILES

CC[C@@H](NC(=O)c1ccc2nc(N[C@H]3CC[C@H](O)CC3)c3nccn3c2c1)c1ccccc1 |r,wU:2.2,13.12,wD:16.16,(23.25,-31.89,;21.92,-31.12,;21.92,-29.58,;20.58,-28.81,;19.25,-29.58,;19.25,-31.12,;17.92,-28.81,;16.58,-29.58,;15.25,-28.81,;15.25,-27.27,;13.92,-26.5,;13.92,-24.96,;12.58,-24.19,;11.25,-24.96,;11.25,-26.5,;9.92,-27.27,;8.58,-26.5,;7.25,-27.27,;8.58,-24.96,;9.92,-24.19,;15.25,-24.19,;15.57,-22.69,;17.1,-22.52,;17.73,-23.93,;16.58,-24.96,;16.58,-26.5,;17.92,-27.27,;23.25,-28.81,;23.25,-27.27,;24.59,-26.5,;25.92,-27.27,;25.92,-28.81,;24.59,-29.58,)|

Structure