Ki Summary

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Target

Heat shock protein 75 kDa, mitochondrial

Ligand

BDBM50368125

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_977708 (CHEMBL2424065)

IC50

55594±n/a nM

Citation

Taldone, T; Patel, PD; Patel, M; Patel, HJ; Evans, CE; Rodina, A; Ochiana, S; Shah, SK; Uddin, M; Gewirth, D; Chiosis, G Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. J Med Chem56:6803-18 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Heat shock protein 75 kDa, mitochondrial

Name:

Heat shock protein 75 kDa, mitochondrial

Synonyms:

HSP75 | TRAP1 | TRAP1_HUMAN

Type:

PROTEIN

Mol. Mass.:

80120.13

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1478164

Residue:

704

Sequence:

MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFS
TQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNA
SDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGS
KAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFE
IAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWM
MDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELG
SSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQ
RLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQL
TSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLR
EFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVT
LRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRAS
EPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH

BDBM50368125

n/a

Name

BDBM50368125

Synonyms:

ADENOSINE DIPHOSPHATE | ADP

Type

Small organic molecule

Emp. Form.

C10H15N5O10P2

Mol. Mass.

427.2011

SMILES

Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|

Structure